Labor Secretary Lori Chavez-DeRemer resigned on April 21, 2026 following a monthslong internal investigation into misconduct allegations including an affair with a subordinate and drinking on the job. She becomes the third Cabinet departure of Trump's second term, following Kristi Noem (fired March 2026) and Pam Bondi (ousted earlier in April). The resignation was confirmed by Reuters, NYT, Time, NPR, and multiple local news outlets, making this one of the most widely corroborated Cabinet departures of the administration.