The WHO's Weekly Epidemiological Record, published continuously since April 1926, is marking its 100th anniversary by shifting to a digital format. Starting as a telegraphed bulletin tracking five diseases under the League of Nations, the WER has evolved into the foundational tool for global disease surveillance and remains the primary record of how public health systems detect and respond to outbreaks. This modernization reflects how epidemiological tracking—the same core mission from a century ago—now moves at digital speed as threats like Ebola, measles, and novel pathogens require real-time coordination across countries.