A peer-reviewed study from University College London analyzing 16,000 patients found that combining gabapentinoids with benzodiazepines doubles the risk of hospitalization for drug poisoning, while adding opioids increases risk by 30%. This matters because gabapentinoids (like gabapentin and pregabalin) are increasingly prescribed for pain and anxiety, and these drug combinations are common in real-world clinical practice—doctors may not always be aware of the compounded risk. The study used a self-controlled case series design analyzing UK hospital records from 2010–2020, making it based on actual hospitalization data rather than theoretical prediction.